Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease
Identifieur interne : 002331 ( Main/Exploration ); précédent : 002330; suivant : 002332Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease
Auteurs : Elizabeth L. Stegemöller [États-Unis] ; Tanya Simuni [États-Unis] ; Colum Mackinnon [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Chemotherapy, Electromyography (methods), Female, Finger, Fingers (physiopathology), Human, Humans, Male, Middle Aged, Movement (drug effects), Movement (physiology), Nervous system diseases, Oscillometry, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Spectrum Analysis (methods), medication, movement frequency, repetitive movements.
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- drug effects : Movement, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- methods : Acoustic Stimulation, Electromyography, Spectrum Analysis.
- pathology : Parkinson Disease.
- physiology : Movement, Psychomotor Performance.
- physiopathology : Fingers, Parkinson Disease.
- chemical , therapeutic use : Antiparkinson Agents.
- Aged, Female, Humans, Male, Middle Aged, Oscillometry.
Abstract
Performance of repetitive hand movements in patients with Parkinson's disease (PD) is characterized by slowness, reduced movement amplitude, and hesitation or arrests in ongoing movement. Currently, the factors and mechanisms contributing to impaired performance of these types of movement remain poorly understood. This study examined the effects of movement frequency and medication on the performance of unconstrained index finger flexion movements in patients with PD and matched control subjects. Movements were synchronized with an auditory tone as the frequency of the tone was increased from 1 to 3 Hz in 0.25 Hz increments. Movement performance was quantified based upon finger kinematics and electromyography (EMG) recorded from the index finger flexors and extensors. The principal finding was that patients with PD showed a dramatic reduction in movement amplitude, an increase in movement frequency, and a loss of phase when the movement frequency reached or exceeded 2 Hz. This deficit was not significantly improved with medications. In contrast, all control subjects could synchronize to 3 Hz. These findings show that movement frequency is a major determinant of hypokinesia during repetitive movements and may contribute to hesitations and movement arrest during clinical testing of bradykinesia in the upper limb of patients with PD. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/97A17723979CA9600C37748B58D4D7F47FE3709C/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754052
DOI: 10.1002/mds.22535
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1162">1162</biblScope><biblScope unit="page" to="1169">1169</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">97A17723979CA9600C37748B58D4D7F47FE3709C</idno><idno type="DOI">10.1002/mds.22535</idno><idno type="ArticleID">MDS22535</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (methods)</term><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Chemotherapy</term><term>Electromyography (methods)</term><term>Female</term><term>Finger</term><term>Fingers (physiopathology)</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (drug effects)</term><term>Movement (physiology)</term><term>Nervous system diseases</term><term>Oscillometry</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Spectrum Analysis (methods)</term><term>medication</term><term>movement frequency</term><term>repetitive movements</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term><term>Electromyography</term><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Fingers</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oscillometry</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Doigt</term><term>Homme</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Performance of repetitive hand movements in patients with Parkinson's disease (PD) is characterized by slowness, reduced movement amplitude, and hesitation or arrests in ongoing movement. Currently, the factors and mechanisms contributing to impaired performance of these types of movement remain poorly understood. This study examined the effects of movement frequency and medication on the performance of unconstrained index finger flexion movements in patients with PD and matched control subjects. Movements were synchronized with an auditory tone as the frequency of the tone was increased from 1 to 3 Hz in 0.25 Hz increments. Movement performance was quantified based upon finger kinematics and electromyography (EMG) recorded from the index finger flexors and extensors. The principal finding was that patients with PD showed a dramatic reduction in movement amplitude, an increase in movement frequency, and a loss of phase when the movement frequency reached or exceeded 2 Hz. This deficit was not significantly improved with medications. In contrast, all control subjects could synchronize to 3 Hz. These findings show that movement frequency is a major determinant of hypokinesia during repetitive movements and may contribute to hesitations and movement arrest during clinical testing of bradykinesia in the upper limb of patients with PD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Stegemoller, Elizabeth L" sort="Stegemoller, Elizabeth L" uniqKey="Stegemoller E" first="Elizabeth L." last="Stegemöller">Elizabeth L. Stegemöller</name></region><name sortKey="Mackinnon, Colum" sort="Mackinnon, Colum" uniqKey="Mackinnon C" first="Colum" last="Mackinnon">Colum Mackinnon</name><name sortKey="Mackinnon, Colum" sort="Mackinnon, Colum" uniqKey="Mackinnon C" first="Colum" last="Mackinnon">Colum Mackinnon</name><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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